Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation.

Embgenbroich, Maria; van der Zande, Hendrik J P; Hussaarts, Leonie; Schulte-Schrepping, Jonas; Pelgrom, Leonard R; García-Tardón, Noemí; Schlautmann, Laura; Stoetzel, Isabel; Händler, Kristian; Lambooij, Joost M; Zawistowska-Deniziak, Anna; Hoving, Lisa; de Ruiter, Karin; Wijngaarden, Marjolein; Pijl, Hanno; Willems van Dijk, Ko; Everts, Bart; van Harmelen, Vanessa; Yazdanbakhsh, Maria; Schultze, Joachim L; Guigas, Bruno; Burgdorf, Sven.

Proc Natl Acad Sci U S A ; 118(31)2021 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-34326259

2.

Plasmodium sporozoites induce regulatory macrophages.

Winkel, Béatrice M F; Pelgrom, Leonard R; van Schuijlenburg, Roos; Baalbergen, Els; Ganesh, Munisha S; Gerritsma, Heleen; de Korne, Clarize M; Duszenko, Nikolas; Langenberg, Marijke C C; Chevalley-Maurel, Séverine C; Smits, Hermelijn H; de Jong, Esther C; Everts, Bart; Franke-Fayard, Blandine; Roestenberg, Meta.

PLoS Pathog ; 16(9): e1008799, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32898164

3.

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type 2 immunity-independent inhibition of food intake.

van der Zande, Hendrik J P; Gonzalez, Michael A; de Ruiter, Karin; Wilbers, Ruud H P; García-Tardón, Noemí; van Huizen, Mariska; van Noort, Kim; Pelgrom, Leonard R; Lambooij, Joost M; Zawistowska-Deniziak, Anna; Otto, Frank; Ozir-Fazalalikhan, Arifa; van Willigen, Danny; Welling, Mick; Poles, Jordan; van Leeuwen, Fijs; Hokke, Cornelis H; Schots, Arjen; Yazdanbakhsh, Maria; Loke, P'ng; Guigas, Bruno.

FASEB J ; 35(2): e21331, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33476078

4.

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

Kaisar, Maria M M; Ritter, Manuel; Del Fresno, Carlos; Jónasdóttir, Hulda S; van der Ham, Alwin J; Pelgrom, Leonard R; Schramm, Gabriele; Layland, Laura E; Sancho, David; Prazeres da Costa, Clarissa; Giera, Martin; Yazdanbakhsh, Maria; Everts, Bart.

PLoS Biol ; 16(4): e2005504, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29668708

5.

Metabolic control of type 2 immunity.

Pelgrom, Leonard R; Everts, Bart.

Eur J Immunol ; 47(8): 1266-1275, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28661041

6.

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.

Boon, Mariëtte R; Kooijman, Sander; van Dam, Andrea D; Pelgrom, Leonard R; Berbée, Jimmy F P; Visseren, Cheryl A R; van Aggele, Robin C; van den Hoek, Anita M; Sips, Hetty C M; Lombès, Marc; Havekes, Louis M; Tamsma, Jouke T; Guigas, Bruno; Meijer, Onno C; Jukema, J Wouter; Rensen, Patrick C N.

FASEB J ; 28(12): 5361-75, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-25154875

7.

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations.

Pelgrom, Leonard R; Davis, Gavin M; O'Shaughnessy, Simon; Wezenberg, Emilie J M; Van Kasteren, Sander I; Finlay, David K; Sinclair, Linda V.

Cell Rep ; 42(8): 112828, 2023 08 29.

Artigo em Inglês | MEDLINE | ID: mdl-37478011

8.

Dendritic cell-intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity.

van der Zande, Hendrik Jp; Brombacher, Eline C; Lambooij, Joost M; Pelgrom, Leonard R; Zawistowska-Deniziak, Anna; Patente, Thiago A; Heieis, Graham A; Otto, Frank; Ozir-Fazalalikhan, Arifa; Yazdanbakhsh, Maria; Everts, Bart; Guigas, Bruno.

JCI Insight ; 8(11)2023 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-37140993

9.

mTORC1 signaling in antigen-presenting cells of the skin restrains CD8⁺ T cell priming.

Pelgrom, Leonard R; Patente, Thiago A; Otto, Frank; Nouwen, Lonneke V; Ozir-Fazalalikhan, Arifa; van der Ham, Alwin J; van der Zande, Hendrik J P; Heieis, Graham A; Arens, Ramon; Everts, Bart.

Cell Rep ; 40(1): 111032, 2022 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-35793635

10.

Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization.

Patente, Thiago A; Pelgrom, Leonard R; Everts, Bart.

Curr Opin Immunol ; 58: 16-23, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-30875606

11.

LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells.

Pelgrom, Leonard R; Patente, Thiago A; Sergushichev, Alexey; Esaulova, Ekaterina; Otto, Frank; Ozir-Fazalalikhan, Arifa; van der Zande, Hendrik J P; van der Ham, Alwin J; van der Stel, Stefan; Artyomov, Maxim N; Everts, Bart.

Cell Res ; 29(5): 406-419, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30940876

12.

Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling.

Kaisar, Maria M M; Pelgrom, Leonard R; van der Ham, Alwin J; Yazdanbakhsh, Maria; Everts, Bart.

Front Immunol ; 8: 1429, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-29163504

13.

Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.

Thwe, Phyu M; Pelgrom, Leonard R; Cooper, Rachel; Beauchamp, Saritha; Reisz, Julie A; D'Alessandro, Angelo; Everts, Bart; Amiel, Eyal.

Cell Metab ; 26(3): 558-567.e5, 2017 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-28877459

14.

Analysis of TLR-Induced Metabolic Changes in Dendritic Cells Using the Seahorse XF(e)96 Extracellular Flux Analyzer.

Pelgrom, Leonard R; van der Ham, Alwin J; Everts, Bart.

Methods Mol Biol ; 1390: 273-85, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-26803635

15.

Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.

Thwe, Phyu M; Pelgrom, Leonard R; Cooper, Rachel; Beauchamp, Saritha; Reisz, Julie A; D'Alessandro, Angelo; Everts, Bart; Amiel, Eyal.

Cell Metab ; 30(1): 225, 2019 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-31269426

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Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation.

Plasmodium sporozoites induce regulatory macrophages.

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type 2 immunity-independent inhibition of food intake.

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

Metabolic control of type 2 immunity.

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations.

Dendritic cell-intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity.

mTORC1 signaling in antigen-presenting cells of the skin restrains CD8⁺ T cell priming.

Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization.

LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells.

Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling.

Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.

Analysis of TLR-Induced Metabolic Changes in Dendritic Cells Using the Seahorse XF(e)96 Extracellular Flux Analyzer.

Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.